Zinc dopamine reddit. Last time this happened only time fixed it.

Zinc dopamine reddit Zinc is an essential trace element required by all organisms for various biological processes. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. Furthermore, zinc supplementation is well known to boost testosterone. May in my case would be worth trying aswell, one of the most basic approeches. Take it with your adderall for a better peak and easier comedown, or take it as the last adderall is wearing off in order to mitigate the comedown almost entirely. and dopamine. You can also have a gene mutation, like I do, which impairs the ability of zinc to get into cells. Dopamine reuptake inhibitors, on the other hand, are unable to cause euphoria, even if they are injected in very high doses. According to this study, high dose Zinc supplementation (60ppm in drinking water, equal to 60mg per day in humans) does not change brain zinc at all: Mice fed high dietary zinc showed significantly increased zinc level in serum and hemocytes, but the total brain zinc level was not changed. Continuous use reduce average dopamine levels. In mice, cocaine decreased striatal vesicular Zn2+ and increased striatal synaptic Zn2 Jun 29, 2017 · Introduction. So, upping your zinc could have fixed that as they are competitive. The fact that you are vegan won t make you automatically deficient in zinc if you eat legumes and nuts. You need to have a baseline stimuli free of bombardment. Increased dopamine receptor density is not necessary for the upregulatory action of Bromantane. Heavy metalswhich can be in the form of cadmium deposits from smoking in my caseblock zinc absorption. This was right at the bottom end of the range, so it didn't quite qualify for deficiency according to the test that I took. The only one that I know of is extract from Nightshade plant. That is made of distilled water, ethyl alcohol, zinc sulfate and b6 p5p Animal studies show that higher zinc levels can decrease dopamine levels by inhibiting iron. The bioavaliabilty of zinc supplements is very low, as little as in the teens depending on type, and the all vary. . Prolactin is known as the anti dopamine hormone so more dopamine offsets it's crap. 30mg elemental zinc appears to be slightly effective as an addition to D-amphetamine therapy. It got rid of my anhedonia, depression, anxiety and what I thought was permanent sexual dysfunction caused by SSRI treatment. 😊 We discuss the wonderful ways the autistic brain functions! Zinc is a surprisingly effective supplement as well, and actually is a subtle dopamine re-uptake inhibitor. I don’t get how people actually benefit from it. Zinc levels and zinc supplementation seems to be a big thing in nutritional psychiatry. AlphaGPC is the one for Acetylcholine, but it does have an unfortunate side-effect because if you take it every day, it feeds some “bad” bacteria in your gut biome, that convert Choline into mildly toxic TMAO. ZMA is not really a good product. If you take Zinc and already have a high copper level, it does do that. Polygala boosts serotonin and dopamine, caffeine works for the dopamine part technically if the stimulation isn't going to make things not good. You can find studies where taking 3 mg of zinc daily reduces the amount of dexamphetamine you have to take to get the same results by 30 %. But vitamin c and tyrosine. Ever since starting zinc supplementation I've started to wonder if I haven't been deficient almost my whole life because I've done a complete 180 when it comes to my anxiety and depression symptoms. ) If your Co/Zn ratio is high noradrenaline increases and dopamine decreases. true. Low dopamine = low libido. The RDA for Zinc is 11mg daily for adults, and the RDA for Zinc is 0. 66 votes, 75 comments. Like zinc gluconate is 14. If estrogen levels get too low in men = low libido. Dopamine is considered to be associated with tons of other effects that have to do with the bigger result of pleasure/euphoria and also more random ones, such as anticipation, repeating behavior, muscle contraction, and more; essentially it plays a big role in the cycle/process of the concept of "reward". Per Dr. Vitex Agnus Castus, also known as Chaste berry, has long been used as a treatment for sexual disorders and insufficiency. Different dopamine receptors can have opposite effects depending on their location in the synapse (pre- or post- synaptic) or in different brain regions. That along with too much cortisol. Zinc and iron blood levels of at least 100. Helps Produce Dopamine. Aug 31, 2020 · Cocaine binds to the dopamine transporter (DAT) in the striatum to regulate cocaine reward and seeking behavior. g. Dopamine releasers cause euphoria in high doses and therefore might pose a risk for people with addictive personalities. If you are low in iron (and thus reduced dopamine synthesis), be sure that you aren’t taking iron or eating iron-rich foods alongside a zinc Zinc can inhibit 5ar. There are a number of ways zinc does this, but some of these include: •prevents your brain from becoming overexcited at NMDA receptors •helps create/regulate serotonin, GABA, dopamine •increases BDNF According to Trudy Scott, the zinc taste test can help determine if you need zinc! Google it! I use zinc, b6, and tyrosine for anti prolactin. average 113 g/d protein diet, histidine would be about 2. That is how you start feeling those weird feelings. Your symptoms are possibly what people refer to as "overmethylation". "The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. In all honesty, it probably only makes a difference if you're a regular user. "Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner. In case supplementing zinc to compensate for possible effects of histidine supplementation, be aware zinc can deplete copper if overdone, such as 50 mg/d zinc long term. Successful antidepressant treatment can raise zinc levels. (Over 80%) You can find liquid zinc sulfate on Amazon for like 15-20 bucks. This can make you feel sleepy, low blood pressure, orthostatic hypotension. Dopamine isn't a simple variable that you can raise or lower within the brain for a desired effect. Each form has a different conversion to elemental zinc. Magnesium Glycinate - 400-600mg / day split over day. gov/pubmed/19000913?dopt=Abstract Wanted to add dopamine beta-hydroxylase (aka dopamine beta-monooxygenase. I have read the correlations of zinc and depression, and supposedly there is some relationship between zinc and schizophrenia/psychosis as well. I started taking a zinc+copper supplement and felt more energy at first, but quickly become overloaded in copper and became extremely irritable. So, a 50mg tab of zinc gluconate would be roughly 7mg of elemental zinc. This could lead to a higher conversion from Dopamine to Norepinephrine and can be counteracted by supplimenting Zinc. I had a similar experience with zinc picolinate though, it seemed I was getting too much zinc. A DRI the mechanism of action at the dopamine transporter (DAT) for dopamine releasers/substrates is entropy-driven (i. 9mg for adults. Tonic dopamine is the rather constant background level, whereas pulsatile are the brief spikes due to some stimulus. The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. https://www. Does the zinc you used contain vitamin B6 also, by the way? Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. They do this in part by reversing the DAT, so that rather than shuttling dopamine back into the neuron, it transports dopamine out of the neuron. Watch his video on dopamine and the analogy of the tidal wave pool. liver, kidneys, brain), then that be affected by taking zinc. I read that max zinc per day is 30-40mg We propose to test our hypothesis by recruiting zinc-deficient ADHD patients who will undergo positron emission tomography with the 11C-raclopride displacement method to investigate whether zinc increases extracellular dopamine levels. I normally have severe social anxiety and symptoms of CPTSD. Edit: It does do that through increasing the testosterone level, through this combination. What others do YOU know? Little educational post attempt here, let's all share our knowledge on this to help each other out. Although zinc is widely prometed as a life changer mineral, it's still a heavy metal and when taken in excess; you won't pee out the unnecessary amount like the case in Vitamin C. I got my levels back a few weeks ago and they are 10 umol/L (or 65 ug/dL). Slow COMT is associated with high tonic dopamine. You end up in higher dopamine state after DBM inhbition. I don’t know exactly how it does it even though it does increase dopamine in the short term, but the side effect is is common enough it’s become a trend among teens to use it as a way to become apathetic. like not nearly enough. Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. Fatigue can be caused through multiple pathways: 1- Lower norepinephrine due to low Dopamine Beta Hydroxylase activity (a Copper enzime that tranaforms dopamine into norepinephrine). According to a 2021 study, zinc does There’s a couple groups that are promoting copper due to deficiencies. Zinc citrate is also good. Amen low dopamine is related to attention problems. We found that cocaine abuse in humans correlated with low postmortem striatal Zn2+ content. 8 mg zinc/kg [21, 68], similarly, we utilized the following diets: zinc-deficient 3 mg zinc/kg; zinc-adequate 50 mg zinc/kg , the study which did Cocaine appears to lower your zinc levels, that's why supplementing seems to help. B-vitamins generally increase methylation levels (the outlier here would be B3) and, in turn, raise monoamine levels (e. However, it wasn't until recently that scientists examined the compounds in the plant and discovered that many of them can reduce prolactin as much as dopamine itself (7). I feel incredible energy, anxiety gone, super social, sex drive sky high. Also there’s zinc lozenges and cold medicine! Edit: missing word possible its the zinc supplement reducing supply of tyrosine. In addition, zinc supports one of the fundamental ingredients for mental health — dopamine. They might be better for people with addictive personalities. Zinc has completely changed my life. A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain. Can attest myself after several years on and off. In large amounts, monoamine releasing agents tend to be neurotoxic. The original formula consists of mag aspartate, and aspartate is excitatory. This way, simple things will give you the dopamine boost. Take 1g a day. Taking a single shot of sulbutiamine increases dopamine release. Folate upregulating production of dopamine and zinc inhibiting dopamine reuptake; the result being the same negative feeling). Zinc promotes gaba production (aswell as glycine) this competes with dopamine and can lower dopamine causing irritability and anger if you are already low! You can try to offset this by taking tyrosine which increases dopamine! Probably not. Nov 3, 2021 · Background Dopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is associated with the progression of a number of neurological diseases, such as Parkinson’s disease. S. nih. After cessation of daily dosing, your dopamine levels will increase, but the sensitization will last for a few months. B6 as pyridoxine HCL is garbage, and P5P can also be stimulating. It does not, at all, potentiate the affects of Adderall. Supplementing zinc has made me feel great. dopamine, serotonin), which some people seem to be unable to properly regulate. According to this study, 30mg elemental zinc daily for 13 weeks (final five weeks used alongside D-amphetamine) was able to reduce the amount of D-amphetamine that was needed by 37% and reduced affective blunting from 21% (placebo with amphetamine) to 11%. Why would this be beneficial if schizophrenia correlated with high dopamine in which zinc supplementation would only increase further? I had via blood test confirming that my zinc levels were on the low end and my doctor wants me to get mine up. The only time to take extra zinc would be at the onset of cold/flu symptoms, and that’s only to lessen the severity/length of the cold/flu. ncbi. The dopamine transporter is regulated by zinc (Zn2+), which directly interacts with the transporter protein as a potent non-competitive blocker of substrate translocation (dopamine transport inward and outward). There are no studies that point to an increase in dopamine or noradrenaline due to concurrent zinc supplementation. Not a place for discussion of illicit and illegal compounds. Creatine: Study Link There are two 'types' of dopamine: tonic and pulsatile. " A plausible explanation is that 5-10% of people of sensitive to supplements and can have strong reactions. I would strongly recommend trying those before trying SAM-e. 20 mg of zinc is very little. , 2014; Nowak, 2015; Prakash et al. The link is strong enough that the degree of zinc deficency can accurately predict the severity of depression. Anyways, stick with those precursors and then stay off of tv and your phone. Stop doing those first and your dopamine will come back and cortisol will lower. 37 mg zinc/kg and the zinc-adequate diet containing 52. Do you mean dopaminergic drug addiction? You can't be addicted to dopamine, part of addiction involves dopamine dysfunction that usually arises from illness, environmental pollution, or most commonly, drug abuse. Dopamine is a neurotransmitter involved in the motivation and reward pathways. iirc zinc has positive effects on dopamine signaling. Zinc defiency can also cause brain fog and ADHD This is a good thing, as it prevents zinc toxicity. L-Tyrosine is my goto/must have for keeping my Dopamine reward system working optimally. Nope, you got it all wrong. Dopa, a precursor of dopamine is oxidatively produced from tyrosine by the copper enzyme tyrosinase. I just joined this group and see that when ppl post, they just say they're taking x amount of zinc but never say in what form. RDA of zinc is 11mg, no one needs that much zinc. Nor does zinc do anything for ADHD if you are not deficient in the mineral. Its general actions are well reviewed, as briefly described in this paper and several excellent reviews (Marger et al. , 2015), but a role for zinc homeostasis with respect to clinical depression and psychosis is not well appreciated by psychiatrists. B vitamins on the other side It's actually not necessarily paradoxical - Zinc potentiates dopamine release by Amphetamine (through DAT allosteric modulation), but at the same time, it might also decrease dopamine production (through inhibition of iron binding to TH). The optimal ratio is said to be anywhere between 8:1 Zinc:Copper to 15:1 Zinc:Copper; there is no universal agreement on the optimal ratio. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown. Last time this happened only time fixed it. Certain pairs of things need to be kept balanced in the body, such as zinc-copper or dopamine-serotonin. Additionally, zinc is a fairly easy nutrition to obtain from food. The idea of "dopamine levels" is more metaphor than science in the nootropics community. Low DHT = low libido. Your symptoms sound like adrenal dysfunction to me. Evidence of this speculation is found with the shared symptoms that result from individual nutrients that have similar effects on specific neurotransmitters (ex. The possible mechanism behind this effect would be the fact that picolinic acid is Dopamine beta-monooxygenase (DBM) inhibitor. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. As a neurotransmitter, dopamine enables the mind and muscle to work together, increasing the benefits that occur from weightlifting. I have heard of selective SSRI in high dosage affecting dopamine. John's Wort. Not recommended. Magnesium is helpful. But I could not find anything suggesting there is such a variant. Whereas the two studies in which increased immobility time in the FST following 2 weeks of the diet utilized the zinc-deficient diet containing 0. Are you sure that's the problem? If you absolutely are sure, then check your zinc/copper levels. Zinc will regulate copper levels. Just off hand I can recall a zinc taste acuity test double blind 300 participant's that also took zinc blood plasma lvls and found the zinc taste test to be pretty damn accurate. Also worth noting that most high-protein foods are going to contain Tyrosine, the amino acid that is a precursor to dopamine. Also giving blood to remove iron due to iron overload in body. I suggest the glycinate form. Zyban. Apparently (too much) zinc can affect brain dopamine binding, you can research this by googling zinc dopamine. Obviously 30 mg is less than the 50 mg tested in the study and is also within the upper limit dose of 40 mg of zinc a day for adults outlined by The National Institutes of Health. Reply reply faxmulder In a U. Or - might be much better - make sure to eat daily 2 tomatos + 1 avocado + 1 paprika + 1 leaf of bok choy + water + salt + eat good meat / fish = and never worry about taking any supps again My parents didn't place much stock on it, who needs zinc right, certainly not a 6 year old! I've honestly felt better on Zinc and Iron supplements, my severe PMS almost vanishes, my mood improves, I don't suffer frequent burnouts, I'm more focused and I'm not fatigued. Summary: Bromantane increases dopamine synthesis, balances excitatory and inhibitory neural networks, and increases neurotrophins by reducing neuroinflammation through epigenetic mechanisms. nlm. Technically speaking, serotonin inhibitors will also work on dopamine since they are both affecting MO, especially nonselective. α-Amidating monooxygenase (α-AE), also called peptidylglycine α-AE, uses copper and ascorbate to remove two car- bons from a C-terminal glycine of peptides, thus generating an amide. It's as if it affects the same symptoms as bupropion, but at different balances. Long-term L-Dopa supplementation has potential to downregulate Dopamine synthesis. Copper and Zinc are Antagonists, a lot of stress and depression can deplete Zinc. This community is focused on neuroscience research of how autism, ADHD, OCD, schizophrenia, schizoaffective etc presents in women. Anhedonia is probably the thing the zinc works most strongly on, it makes me very excited about things. Dopamine reuptake inhibitors, such as cocaine, block the influx of dopamine (intake of dopamine from the synapse back into the neuron. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , Wellbutrin SR and XL A common long term side effect for ashwaganda is reported to be anhedonia. A daily intake of 60 mg of zinc for 10 weeks (10 mg from the diet and 50 mg from a zinc supplement) was associated with a decrease in copper status. Novos labs longevity protocol says to take them separately because they compete for similar pathways. It keeps my ratio where it needs to be, and I've only ever struggled with zinc deficiency not copper. DBM normally converts dopamine to norepinephrine. Copper is an antagonist of zinc and can cause a host of problems, especially for men since we're supposed to be Zinc dominant because Zinc plays a huge role in the production of testosterone, the inhibition of prolactin which suppresses dopamine and prolactin, and also the production of dopamine. Zinc should not be taken with other metal supplements like iron as they compete for absorption. Dopamine addiction is not a thing. Zinc increase dopamine and testosterone and both can increase arousal even in non deficient people . My sensory processing sensitivities become more manageable. If you have hidden copper toxicity - excess copper stored in the tissues (i. Also consider also using topical DIY Zix for further non systemic topical DHT reduction. I couldn’t get my copper levels up to “in range” so i just settled on a 15mg zinc glycinate daily I took 40 mg of combined zinc biglycinate + zinc picolinate, and I have seen a pretty alarming decline in work motivation. I’ve done this and it’s worked great but… I was wondering what are some other ways you can increase your dopamine naturally ? I’m really struggling to focus these days even though I’m on But I also don't know how dopamine would be low and norepinephrine would be high unless the enzyme DBH - which converts dopamine to norepi - had some variant which upregulates the conversion rate. ---nap . Zinc can lower estrogen. Jarrow Zinc Balance is a nice low dose of zinc and copper 15mg:1mg. The fact that dysfunction of the dopamine transporter is involved in the pathogenesis of … Having Zinc at the same time as your meds will definitely potentiate Adderall. Not only is dopamine important for muscle building benefits, but it can also counteract depression. Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. I did seem to have an increase in mood (or I should say a reduction in negative mood), but noticed I was putting on water weight. Apparently Zinc is a natural dopamine reuptake inhibitor. I started taking 50 mg of P5P at my doctor's recommendation in order to increase dopamine; B6 is a major cofactor for speeding up the enzyme that converts l-dopa to dopamine but also histidine to histamine. 35% elemental zinc by wright. Tyrosine allows our body to create the dopamine that stimulant medications will be releasing, eating lots of protein can also heavily mitigate the comedown or “crash” the meds bring on. I cut one 25mg pill to half and take a half every day, that’s all you need. There’s 2 camps that vary in some of the subtleties but they’re both pro copper, iodine, b vitamins, real vit C and then it seems to vary on zinc & other minerals supplements depending on your body make up and general health. Dopamine-β-Hydroxylase has 2 cofactors copper and Vit C. It may help relieve ADHD symptoms if you are Zinc deficient. IT is a rate iimited dopamine precursor. Dec 27, 2024 · I got 160mg of zinc citrate supps of which 50mg is elemental zinc but that seems too high. edu Mar 28, 2022 · Lower levels of zinc have been linked to symptoms of depression and anxiety. This is a good reminder that if you are taking zinc as a supplement, it can interact with iron absorption. Still, both are significantly different than what is in the brand you have been taking. Have had that experience with both Vyvanse and Dexamphetamine Dopamine based stimulants will deplete your Sodium levels so make sure you're getting enough of your electrolytes; Sodium, Potassium etc. Excess copper converts your dopamine to norepinephrine, I felt psychotic and it took a couple of days supplementing zinc alone to feel normal again. The study is specifically with cocaine addicted mice, and basically zinc made them do more coke than usual (presumably because it made it better, dopamine is the best part of coke). Zinc gluconate has been much more effective for me. e. These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) Hello everyone, In the episode about dopamine,Huberman says that you can raise your base line “wavepool” of dopamine by taking a cold shower. Increasing your daily zinc intake can help improve symptoms. Using co-forms of zinc that have other uses in the body like zinc sulfate, (which you are) and zinc glycinate instead of zinc picolinate or zinc gluconate is superior as picolinate & gluconate are worthless binding agents once cleaved from the zinc in digestion. Theoretically same for Zinc - Copper pair Maybe you should look into electrolytes, and drink a mix of potassium + magnesium + salt + zinc. D of 80. Nov 13, 2021 · The link between iron and zinc supplementation and the observed decrease in ADHD symptoms in the controlled clinical trials selected for this systematic review also makes sense with regard to the role of zinc and iron as dopamine reuptake inhibitors, which was precisely the core target of the stimulant medications used in the combined treatment Perfect! Then definitely don’t take extra zinc. If you don't have a high copper level and take both Zinc and Copper, it does do that as well. This makes the pulses of dopamine small in comparison. hydrophobic), whereas for dopamine re-uptake inhibitors it is enthalpy-driven (i. The symptoms of Autism include a lack of willingness to make eye contact, repeated tasks etsWhich some studies were ameliorated with glycine, arginine, zinc, and creatine ( I can't find the study at the moment)My current stack is: Lysine, acetyl L carnitine, COQ10, Zinc, selenium, vitamin C and Iron ( every two days) and probiotics For example, a Harvard article titled "Nutrition's dynamic duos" discusses the effects of high amounts of zinc causing copper deficiency so they recommend adding copper to zinc supplements. Zinc antagonizes copper - you might be feeling the effects of the copper being stirred up and overstimulating the nervous system. All this is good, but the problem is that while zinc is the signal for producing metallothioneins, these proteins bind to copper better than they do to zinc. The results of the present study indicate that zinc supplementation together with SSRIs antidepressant drug improves major depressive disorders more effectively in patients with placebo plus antidepressants (SSRIs). to get 20 mg of zinc can take upwards of 200 mgs of zinc supplements and if your doing that then throw in some copper Zinc plays a large role in how we react to stress and deficiency is linked to depression. Due to its critical functions, DA expression levels in the brain are tightly controlled, with one important and rate-limiting step in its I've recent been taking Maca and the effects have been huge for me. If both occur at the same time, though, Amphetamine could deplete dopamine stores faster. Also there are distinct metabotropic receptors that bind zinc in the brain and an immediate search pulls up a journal article that mentions it has interactions with AMPArs and 5HT1Ars + mTOR among other places. Zinc inhibits prolactin in the CNS, increases thyroid hormone activity and antagonizes NMDA receptors. It is also anecdotally reported to give people vivid dreams and a significant increase in appetite, 2 effects commonly seen in people who use dopamine agonists. Zinc is also said to be stimulating as it is possibly a weak dopamine reuptake inhibitor. Quecertin helps. BUT: When you first start taking zinc, it might make you feel like it's having the opposite effect. Keep in mind you also get zinc from foods as well, so you are likely overdosing on zinc without even realizing. Zinc is very efficient at depleting copper. If you maintain this for several weeks your receptors will increase their sensitivity to return you to baseline. Copper supplementation is necessary to prevent deficiency when supplementing high dose zinc, however at 30mg zinc per day you should be fine. The 4 supplements are: Zinc, Creatine, NAC and Fish Oil Zinc: Study Link. Just commenting for balance. conformational change). Herein, we report a host-cell-specific direction of the Zn(2+ … Hi, we likely have the same issue. I've taken several other forms of zinc, but none of them had an effect. It's a tricky & complicated balance. yeah my first panel showed a slight deficiency in both zinc and copper, i started zinc and watched my copper deficiency get worse so i began taking 2mg copper bisglycinate alongside (but at different times) 30mg zinc picolinate. When you get your dopamine, research increasing dopamine receptor density. Copper is involved in dopamine. Your common SSRI that is probably the most effective is St. " Zinc acts as a dopamine reuptake inhibitor and is also supposed to act as an antidepressant. 5 grams. Excess copper leads to higher epinephrine production, tanking dopamine. Feel amazing after pmo as opposed to depressed, with brain fog etc. Drugs like ecstasy or molly blow all your dopamine levels and take many days to replenish. These epithelial cells shed every 5-6 days, and the metallothioneins with their bound excess zinc are shed too, and excreted in feces. Zinc can potentially affect dopamine transmission/synthesis by depleting copper. L-tyrosine or N-acetyl-l-tyrosine are better options that will effectively raise dopamine levels and are safe to supplement long-term, although work even better when cycled. qqalbu frswyj sbzv zdv emflqcdx ldxamn dhg qtufz ukvtl gqrkj gfqk ippl bdkzeq tpmkve dptwy